SBE2
Gene Ontology Biological Process
Gene Ontology Cellular Component
BCK1
Gene Ontology Biological Process
- endoplasmic reticulum unfolded protein response [IMP]
- establishment of cell polarity [IMP]
- intracellular signal transduction [IMP]
- peroxisome degradation [IMP]
- protein phosphorylation [IDA, TAS]
- regulation of fungal-type cell wall organization [IGI, IMP]
- response to acidic pH [IMP]
- response to nutrient [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Sbe2p and sbe22p, two homologous Golgi proteins involved in yeast cell wall formation.
The cell wall of fungal cells is important for cell integrity and cell morphogenesis and protects against harmful environmental conditions. The yeast cell wall is a complex structure consisting mainly of mannoproteins, glucan, and chitin. The molecular mechanisms by which the cell wall components are synthesized and transported to the cell surface are poorly understood. We have identified and characterized ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- observed in sbe22 deletion mutant background, i.e. sbe2 sbe22 bck1 triple mutant shows a synthetic lethal interaction
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BCK1 SBE2 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | High | -0.32 | BioGRID | 909681 |
Curated By
- BioGRID