MAK21
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SKI6
Gene Ontology Biological Process
- U1 snRNA 3'-end processing [IGI, IMP]
- U4 snRNA 3'-end processing [IGI, IMP]
- U5 snRNA 3'-end processing [IGI, IMP]
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- nonfunctional rRNA decay [IC]
- nuclear mRNA surveillance [IGI, IMP]
- nuclear polyadenylation-dependent CUT catabolic process [IMP]
- nuclear polyadenylation-dependent mRNA catabolic process [IC]
- nuclear polyadenylation-dependent tRNA catabolic process [IDA]
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [IGI, IMP]
- nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [IMP]
- nuclear-transcribed mRNA catabolic process, non-stop decay [IC]
- polyadenylation-dependent snoRNA 3'-end processing [IMP]
- rRNA catabolic process [IMP]
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis.
Mak21-1 mutants are unable to propagate M1 double-stranded RNA, a satellite of the L-A double-stranded RNA virus, encoding a secreted protein toxin lethal to yeast strains that do not carry M1. We cloned MAK21 using its map location and found that Mak21p is homologous to a human and mouse CAATT-binding protein and open reading frames in Schizosaccharomyces pombe and Caenorhabditis ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: rna accumulation (APO:0000224)
Additional Notes
- ski mutants suppress the defect in Mak21-1 mutants in which they are unable to propagate M1 double-stranded RNA, a satellite of the L-A double-stranded RNA virus
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAK21 SKI6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1646 | BioGRID | 1925241 | |
| SKI6 MAK21 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1732 | BioGRID | 1935501 |
Curated By
- BioGRID