YAF9
Gene Ontology Biological Process
Gene Ontology Cellular Component
TAF14
Gene Ontology Biological Process
- RNA polymerase II transcriptional preinitiation complex assembly [IC]
- chromatin remodeling [IC]
- histone acetylation [IDA]
- nucleosome mobilization [IDA]
- promoter clearance from RNA polymerase II promoter [IC]
- transcription elongation from RNA polymerase II promoter [IC]
- transcription from RNA polymerase II promoter [IDA]
- transcription initiation from RNA polymerase II promoter [IDA]
- transcriptional start site selection at RNA polymerase II promoter [IC]
Gene Ontology Molecular Function- DNA translocase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [IC]
- core RNA polymerase II binding transcription factor activity [IDA]
- core RNA polymerase II recruiting transcription factor activity [IC]
- DNA translocase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [IC]
- core RNA polymerase II binding transcription factor activity [IDA]
- core RNA polymerase II recruiting transcription factor activity [IC]
Gene Ontology Cellular Component
- Ino80 complex [IDA, IPI]
- NuA3 histone acetyltransferase complex [IDA]
- NuA3a histone acetyltransferase complex [IDA]
- NuA3b histone acetyltransferase complex [IDA]
- SWI/SNF complex [IDA, IPI]
- mediator complex [IPI]
- nucleus [IDA]
- transcription factor TFIID complex [IDA]
- transcription factor TFIIF complex [IDA, IPI]
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres.
Yaf9, Taf14, and Sas5 comprise the YEATS domain family in Saccharomyces cerevisiae, which in humans includes proteins involved in acute leukemias. The YEATS domain family is essential, as a yaf9Delta taf14Delta sas5Delta triple mutant is nonviable. We verify that Yaf9 is a stable component of NuA4, an essential histone H4 acetyltransferase complex. Yaf9 is also associated with the SWR1 complex, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- in taf14 sas5 background
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TAF14 YAF9 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -11.5648 | BioGRID | 213831 | |
| YAF9 TAF14 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low/High | - | BioGRID | 285930 |
Curated By
- BioGRID