BAIT
GATA1
ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT
GATA binding protein 1 (globin transcription factor 1)
GO Process (22)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- basophil differentiation [IEP]
- blood coagulation [TAS]
- cellular response to thyroid hormone stimulus [IDA]
- eosinophil differentiation [IEP]
- eosinophil fate commitment [IDA]
- erythrocyte development [IMP]
- erythrocyte differentiation [IEP]
- male gonad development [IMP]
- megakaryocyte differentiation [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription regulatory region DNA binding [IDA]
- platelet aggregation [IMP]
- platelet formation [IMP]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of definitive erythrocyte differentiation [IDA]
- regulation of glycoprotein biosynthetic process [IMP]
- transcription from RNA polymerase II promoter [IDA]
- transcriptional activation by promoter-enhancer looping [ISS]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- chromatin DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IMP]
- C2H2 zinc finger domain binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- chromatin DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
ZFPM2
DIH3, FOG2, SRXY9, ZC2HC11B, ZNF89B, hFOG-2
zinc finger protein, FOG family member 2
GO Process (8)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- blood coagulation [TAS]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- negative regulation of transcription, DNA-templated [IDA]
- outflow tract septum morphogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- right ventricular cardiac muscle tissue morphogenesis [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IBA]
- RNA polymerase II transcription coactivator activity [NAS]
- RNA polymerase II transcription factor binding [IBA]
- protein binding [IPI]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- zinc ion binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IBA]
- RNA polymerase II transcription coactivator activity [NAS]
- RNA polymerase II transcription factor binding [IBA]
- protein binding [IPI]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- zinc ion binding [NAS]
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IBA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation.
We have identified a novel human zinc finger protein, hFOG-2, which is related to but distinct from the murine transcription factor Friend-of-GATA-1 (mFOG-1). The hFOG-2 gene was initially detected in K562 cells using a polymerase chain reaction approach with degenerate primers corresponding to zinc finger regions of mFOG-1. A murine homologue of hFOG-2 was also identified in the mouse expressed ... [more]
J. Biol. Chem. Aug. 13, 1999; 274(33);23491-8 [Pubmed: 10438528]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ZFPM2 GATA1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID