RAD51
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YAP1
Gene Ontology Biological Process
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IMP]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to drug [IMP]
- response to heat [IMP]
- response to metal ion [IMP]
- response to singlet oxygen [IMP]
Gene Ontology Molecular Function
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae.
Reactive oxygen species (ROS)-mediated DNA adducts as well as DNA strand breaks are highly mutagenic leading to genomic instability and tumorigenesis. DNA damage repair pathways and oxidative stress response signaling have been proposed to be highly associated, but the underlying interaction remains unknown. In this study, we employed mutant strains lacking Rad51, the homolog of E. coli RecA recombinase, and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: mutation frequency (APO:0000198)
- phenotype: protein/peptide modification (APO:0000131)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- rad51 yap1 and rad51 skn7 double mutants displayed much more sensitive phenotypes than either of single mutants in response to both oxidative stresses and DNA damaging agents and revealed more than just additive effects in their sensitivities suggesting those two damage response pathways are not independent, they also had increased mutation frequencies and high levels of phosphorylated rad53
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD51 YAP1 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 1870004 | |
| YAP1 RAD51 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.7684 | BioGRID | 541239 | |
| RAD51 YAP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1998 | BioGRID | 375687 | |
| YAP1 RAD51 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1998 | BioGRID | 403621 | |
| RAD51 YAP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1209 | BioGRID | 2109045 | |
| YAP1 RAD51 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1842 | BioGRID | 2157245 | |
| RAD51 YAP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.2981 | BioGRID | 324824 | |
| RAD51 YAP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 3492639 | |
| RAD51 YAP1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 457177 |
Curated By
- BioGRID