MPS1
Gene Ontology Biological Process
- mitotic spindle assembly checkpoint [IGI, IMP]
- protein autophosphorylation [IDA]
- protein localization to kinetochore [IGI]
- protein phosphorylation [IDA, IMP]
- regulation of attachment of spindle microtubules to kinetochore [IMP]
- sister chromatid biorientation [IMP]
- spindle assembly [IMP]
- spindle pole body duplication [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IPL1
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore [IMP]
- chromosome segregation [IMP]
- homologous chromosome segregation [IMP]
- meiotic sister chromatid segregation [IMP]
- mitotic DNA integrity checkpoint [IGI]
- mitotic spindle disassembly [IMP]
- negative regulation of protein import into nucleus during spindle assembly checkpoint [IMP]
- positive regulation of spindle checkpoint [IMP]
- protein phosphorylation [IDA, IMP]
- regulation of cytokinesis [IMP]
- regulation of spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global genetic interaction network maps a wiring diagram of cellular function.
We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to ... [more]
Quantitative Score
- -0.5601 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions.
- alleles: mps1-3796 - ipl1-1 [SGA score = -0.3670, P-value = 9.878E-11]
- alleles: mps1-3796 - ipl1-2 [SGA score = -0.5601, P-value = 0]
- alleles: mps1-417 - ipl1-1 [SGA score = -0.1726, P-value = 0.0007575]
- alleles: mps1-417 - ipl1-2 [SGA score = -0.2655, P-value = 3.465E-7]
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IPL1 MPS1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2898 | BioGRID | 1955601 | |
| MPS1 IPL1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156994 | |
| MPS1 IPL1 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.2634 | BioGRID | 1871222 |
Curated By
- BioGRID