CDC7
Gene Ontology Biological Process
- DNA replication initiation [IMP]
- double-strand break repair via break-induced replication [IMP]
- negative regulation of exit from mitosis [IPI]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of meiosis I [IGI]
- positive regulation of meiotic DNA double-strand break formation [IGI]
- premeiotic DNA replication [IMP]
- protein phosphorylation [IMP]
- regulation of chromatin silencing at telomere [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CTF8
Gene Ontology Biological Process
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global genetic interaction network maps a wiring diagram of cellular function.
We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to ... [more]
Quantitative Score
- -0.3973 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions.
- alleles: cdc7-1 - ctf8-162 [SGA score = -0.2320, P-value = 1.452E-8]
- alleles: cdc7-1 - ctf8-9 [SGA score = -0.2700, P-value = 3.696E-5]
- alleles: cdc7-4 - ctf8 [SGA score = -0.2655, P-value = 0.0003131]
- alleles: cdc7-4 - ctf8-162 [SGA score = -0.2697, P-value = 1.93E-5]
- alleles: cdc7-4 - ctf8-9 [SGA score = -0.3973, P-value = 1.082E-17]
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC7 CTF8 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1328 | BioGRID | 364818 | |
| CTF8 CDC7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4505 | BioGRID | 2048408 | |
| CDC7 CTF8 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.5689 | BioGRID | 2428453 | |
| CDC7 CTF8 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 451530 |
Curated By
- BioGRID