PHO85
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IGI, IMP]
- fungal-type cell wall organization [IGI]
- negative regulation of calcium-mediated signaling [IGI]
- negative regulation of glycogen biosynthetic process [IMP]
- negative regulation of macroautophagy [IMP]
- negative regulation of phosphate metabolic process [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of macroautophagy [IMP]
- protein phosphorylation [IDA]
- regulation of establishment or maintenance of cell polarity [IGI]
- regulation of protein localization [IDA]
- regulation of protein stability [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ROM2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Combining chemical genetics and proteomics to identify protein kinase substrates.
Phosphorylation is a ubiquitous protein modification important for regulating nearly every aspect of cellular biology. Protein kinases are highly conserved and constitute one of the largest gene families. Identifying the substrates of a kinase is essential for understanding its cellular role, but doing so remains a difficult task. We have developed a high-throughput method to identify substrates of yeast protein ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PHO85 ROM2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 81895 | |
| ROM2 PHO85 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 692013 | |
| PHO85 ROM2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 450225 |
Curated By
- BioGRID