A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Mutator phenotype induced by aberrant replication.

Liu VF, Bhaumik D, Wang TS

We have identified thermosensitive mutants of five Schizosaccharomyces pombe replication proteins that have a mutator phenotype at their semipermissive temperatures. Allele-specific mutants of DNA polymerase delta (poldelta) and mutants of Polalpha, two Poldelta subunits, and ligase exhibited increased rates of deletion of sequences flanked by short direct repeats. Deletion of rad2(+), which encodes a nuclease involved in processing Okazaki fragments, ... [more]

Mol. Cell. Biol. Feb. 01, 1999; 19(2);1126-35 [Pubmed: 9891047]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
POL1 RAD26	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Kai M (2003)	Low	-	BioGRID	927708
POL1 RAD26	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Bhaumik D (1998)	Low	-	PomBase	-

Curated By

BioGRID

Interaction Summary

RAD26

Gene Ontology Biological Process

Gene Ontology Cellular Component

POL1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA replication origin binding [IDA]DNA-directed DNA polymerase activity [IDA, IGI]chromatin binding [IDA]protein binding [IPI]single-stranded DNA binding [IDA]