DOA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
RAD14
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast.
A competitive growth assay has been used to identify yeast genes involved in the repair of UV- or MMS-induced DNA damage. A collection of 2,827 yeast strains was analyzed in which each strain has a single ORF replaced with a cassette containing two unique sequence tags, allowing for its detection by hybridization to a high-density oligonucleotide array. The hybridization data ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: uv resistance (APO:0000085)
- phenotype: resistance to chemicals (APO:0000087)
Additional Notes
- Additive sensitivity to MMS and UV compared to single mutants
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RAD14 DOA1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.8532 | BioGRID | 219843 |
Curated By
- BioGRID