SGV1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SET2
Gene Ontology Biological Process
- DNA-templated transcription, elongation [IDA, IPI]
- DNA-templated transcription, termination [IMP]
- ascospore formation [IMP]
- histone deacetylation [IMP]
- histone methylation [IDA, IMP]
- negative regulation of antisense RNA transcription [IMP]
- negative regulation of histone H3-K14 acetylation [IMP]
- negative regulation of histone H3-K9 acetylation [IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- positive regulation of histone acetylation [IGI]
- regulation of DNA-dependent DNA replication initiation [IMP]
- regulation of histone exchange [IMP]
- regulation of transcription, DNA-templated [IDA, IMP]
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.
BUR1 and BUR2 encode the catalytic and regulatory subunits of a cyclin-dependent protein kinase complex that is essential for normal growth and has a general role in transcription elongation. To gain insight into its specific role in vivo, we identified mutations that reverse the severe growth defect of bur1Delta cells. This selection identified mutations in SET2, which encodes a histone ... [more]
Throughput
- Low Throughput
Ontology Terms
- viability (APO:0000111)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SET2 SGV1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 3502727 | |
| SET2 SGV1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1396 | BioGRID | 2051673 | |
| SGV1 SET2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1941 | BioGRID | 2024832 | |
| SGV1 SET2 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 3388446 | |
| SGV1 SET2 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 1870183 | |
| SGV1 SET2 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 2745982 |
Curated By
- BioGRID