BAIT

TLC1

TER1, L000002315

RNA template component of telomerase; TLC1 RNA contains a template sequence that Est2p uses to add irregular repeats of TG(1-3) residues onto a DNA end; promoter regulated by the cell cycle dependent transcriptional activators Swi4p/Swi6p and Mbp1p/Swi6p

GO Process (2)

GO Function (2)

GO Component (4)

Gene Ontology Biological Process

telomere maintenance via recombination [IMP]

telomere maintenance via telomerase [IDA, IMP]

Gene Ontology Molecular Function

telomerase activity [IDA]
template for synthesis of G-rich strand of telomere DNA activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleus [IDA]

telomerase catalytic core complex [IDA, IPI]

telomerase holoenzyme complex [IDA, IPI]

SGD Alliance of Genome Resources Entrez Gene

Saccharomyces cerevisiae (S288c)

PREY

STP1

BAP1, SSY2, L000002132, YDR463W

Transcription factor; contains a N-terminal regulatory motif (RI) that acts as a cytoplasmic retention determinant and as an Asi dependent degron in the nucleus; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication

GO Process (2)

GO Function (2)

GO Component (3)

Gene Ontology Biological Process

positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISS]

positive regulation of transcription, DNA-templated [IDA]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleus [IDA]

plasma membrane [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae.

Kyriakou D, Stavrou E, Demosthenous P, Angelidou G, San Luis BJ, Boone C, Promponas VJ, Kirmizis A

Transcriptome studies have revealed that many eukaryotic genomes are pervasively transcribed producing numerous long non-coding RNAs (lncRNAs). However, only a few lncRNAs have been ascribed a cellular role thus far, with most regulating the expression of adjacent genes. Even less lncRNAs have been annotated as essential hence implying that the majority may be functionally redundant. Therefore, the function of lncRNAs ... [more]

BMC Biol. Dec. 07, 2016; 14(1);106 [Pubmed: 27927215]

Throughput

Low Throughput

Additional Notes

Curated By

BioGRID

Interaction Summary

TLC1

Gene Ontology Biological Process

Gene Ontology Molecular Function

telomerase activity [IDA]template for synthesis of G-rich strand of telomere DNA activity [TAS]

Gene Ontology Cellular Component

STP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]

Gene Ontology Cellular Component

Negative Genetic

Publication

Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae.

Throughput

Additional Notes

Curated By

telomerase activity [IDA]
template for synthesis of G-rich strand of telomere DNA activity [TAS]

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]