BAIT
PHO85
LDB15, cyclin-dependent serine/threonine-protein kinase PHO85, phoU, L000001431, YPL031C
Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
GO Process (14)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IGI, IMP]
- fungal-type cell wall organization [IGI]
- negative regulation of calcium-mediated signaling [IGI]
- negative regulation of glycogen biosynthetic process [IMP]
- negative regulation of macroautophagy [IMP]
- negative regulation of phosphate metabolic process [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of macroautophagy [IMP]
- protein phosphorylation [IDA]
- regulation of establishment or maintenance of cell polarity [IGI]
- regulation of protein localization [IDA]
- regulation of protein stability [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
MIG1
CAT4, SSN1, TDS22, transcription factor MIG1, L000001110, YGL035C
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter by glucose [IDA, IGI, IMP]
- positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library.
Kinases and transcription factors (TFs) are key modulators of important signaling pathways and their activities underlie the proper function of many basic cellular processes such as cell division, differentiation and development. Changes in kinase and TF dosage are often associated with disease, yet a systematic assessment of the cellular phenotypes caused by the combined perturbation of kinases and TFs has ... [more]
G3 (Bethesda) Jan. 25, 2017; 0(0); [Pubmed: 28122947]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID