BAIT
CLB5
B-type cyclin CLB5, L000000353, YPR120C
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication
GO Process (7)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IEP, IMP]
- G2/M transition of mitotic cell cycle [IEP, IMP]
- positive regulation of DNA replication [IMP]
- positive regulation of spindle pole body separation [IGI]
- premeiotic DNA replication [IGI, IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- spindle assembly [IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
WTM1
L000003515, YOR230W
Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
GO Process (6)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- maintenance of protein location in nucleus [IMP]
- negative regulation of chromatin silencing at silent mating-type cassette [IGI]
- negative regulation of chromatin silencing at telomere [IGI]
- negative regulation of transcription from RNA polymerase II promoter during meiosis [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- protein import into nucleus [IMP, IPI]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library.
Kinases and transcription factors (TFs) are key modulators of important signaling pathways and their activities underlie the proper function of many basic cellular processes such as cell division, differentiation and development. Changes in kinase and TF dosage are often associated with disease, yet a systematic assessment of the cellular phenotypes caused by the combined perturbation of kinases and TFs has ... [more]
G3 (Bethesda) Jan. 25, 2017; 0(0); [Pubmed: 28122947]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID