BAIT
AURKA
AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, RP5-1167H4.6
aurora kinase A
GO Process (13)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [IBA]
- negative regulation of protein binding [IDA]
- positive regulation of mitosis [TAS]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of centrosome cycle [TAS]
- regulation of cytokinesis [IBA]
- regulation of protein stability [IMP]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA, TAS]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- cytosol [TAS]
- microtubule cytoskeleton [IDA]
- midbody [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- spindle [TAS]
- spindle microtubule [IDA]
- spindle midzone [IBA]
- spindle pole centrosome [IDA]
Homo sapiens
PREY
GTF3C4
KAT12, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA
general transcription factor IIIC, polypeptide 4, 90kDa
GO Process (8)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- 5S class rRNA transcription from RNA polymerase III type 1 promoter [IC]
- gene expression [TAS]
- histone acetylation [TAS]
- positive regulation of catalytic activity [TAS]
- tRNA transcription from RNA polymerase III promoter [IC]
- transcription from RNA polymerase III promoter [IC, TAS]
- transcription initiation from RNA polymerase III promoter [TAS]
- transcription, DNA-templated [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.
Aurora kinase A (AURKA) has been implicated in the regulation of cell cycle progression, mitosis and a key number of oncogenic signaling pathways in various malignancies. However, little is known about its role in gastric cancer prognosis and genotoxic resistance. Here we found that AURKA was highly overexpressed in gastric cancer and inversely correlated with disease prognosis. Overexpression of AURKA ... [more]
Oncogenesis Feb. 20, 2017; 6(2);e298 [Pubmed: 28218735]
Throughput
- Low Throughput
Curated By
- BioGRID