AURKA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [IBA]
- negative regulation of protein binding [IDA]
- positive regulation of mitosis [TAS]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of centrosome cycle [TAS]
- regulation of cytokinesis [IBA]
- regulation of protein stability [IMP]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA, TAS]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- cytosol [TAS]
- microtubule cytoskeleton [IDA]
- midbody [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- spindle [TAS]
- spindle microtubule [IDA]
- spindle midzone [IBA]
- spindle pole centrosome [IDA]
TFAP2B
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- calcium ion homeostasis [ISS]
- cellular ammonia homeostasis [ISS]
- cellular creatinine homeostasis [ISS]
- cellular urea homeostasis [ISS]
- collecting duct development [ISS]
- distal tubule development [ISS]
- ductus arteriosus closure [ISS]
- fat cell differentiation [IEP]
- forelimb morphogenesis [ISS]
- glucose homeostasis [ISS]
- glucose metabolic process [IMP]
- hindlimb morphogenesis [ISS]
- kidney development [ISS]
- magnesium ion homeostasis [ISS]
- negative regulation of apoptotic process [IDA, ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- phosphate ion homeostasis [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of urine volume [ISS]
- potassium ion homeostasis [ISS]
- regulation of BMP signaling pathway [ISS]
- regulation of cell differentiation [IDA]
- regulation of insulin secretion [IMP]
- regulation of transcription, DNA-templated [IDA]
- renal water homeostasis [ISS]
- retina layer formation [IEP]
- sodium ion homeostasis [ISS]
- sympathetic nervous system development [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription coactivator activity [ISS]
- RNA polymerase II transcription corepressor activity [ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- enhancer sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- DNA binding [TAS]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription coactivator activity [ISS]
- RNA polymerase II transcription corepressor activity [ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- enhancer sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.
Aurora kinase A (AURKA) has been implicated in the regulation of cell cycle progression, mitosis and a key number of oncogenic signaling pathways in various malignancies. However, little is known about its role in gastric cancer prognosis and genotoxic resistance. Here we found that AURKA was highly overexpressed in gastric cancer and inversely correlated with disease prognosis. Overexpression of AURKA ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID