BAIT
CDC73
C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
cell division cycle 73
GO Process (17)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- endodermal cell fate commitment [ISS]
- histone H2B ubiquitination [IDA]
- histone monoubiquitination [IDA]
- mRNA polyadenylation [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of mRNA 3'-end processing [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein destabilization [IMP]
- stem cell maintenance [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB8A
MEL, RAB8
RAB8A, member RAS oncogene family
GO Process (15)
GO Function (6)
GO Component (16)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- GTP catabolic process [IBA, IDA]
- Golgi vesicle fusion to target membrane [IDA]
- Rab protein signal transduction [IBA]
- axonogenesis [ISS]
- cellular response to insulin stimulus [IBA, ISS]
- cilium assembly [IDA, IMP]
- intracellular protein transport [IBA]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- protein localization to plasma membrane [IBA, ISS]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- centrosome [IDA]
- cilium [IDA]
- cytoplasmic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- nonmotile primary cilium [IDA]
- nucleolus [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- phagocytic vesicle [IDA]
- plasma membrane [IBA, IDA]
- primary cilium [IDA]
- recycling endosome membrane [IDA]
- secretory granule membrane [IBA]
- synaptic vesicle [IBA]
- trans-Golgi network transport vesicle [IBA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.
To identify new regulators of homologous recombination repair, we carried out a genome-wide short-interfering RNA screen combined with ionizing irradiation using RAD51 foci formation as readout. All candidates were confirmed by independent short-interfering RNAs and validated in secondary assays like recombination repair activity and RPA foci formation. Network analysis of the top modifiers identified gene clusters involved in recombination repair ... [more]
Cell Discov Jan. 01, 2015; 1();15034 [Pubmed: 27462432]
Throughput
- High Throughput
Curated By
- BioGRID