PIK3R1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to insulin stimulus [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- growth hormone receptor signaling pathway [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA, IPI]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- positive regulation of RNA splicing [IMP]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of transcription factor import into nucleus [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- protein stabilization [IDA]
- regulation of phosphatidylinositol 3-kinase activity [ISS]
- response to endoplasmic reticulum stress [IDA, ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA]
- insulin binding [IDA]
- insulin receptor binding [IPI]
- insulin receptor substrate binding [ISS]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [ISS]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- transcription factor binding [IPI]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISS]
- ErbB-3 class receptor binding [IDA]
- insulin binding [IDA]
- insulin receptor binding [IPI]
- insulin receptor substrate binding [ISS]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [ISS]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- transcription factor binding [IPI]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISS]
Gene Ontology Cellular Component
CBLB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.
Cbl-b, a ring-type E3 ubiquitin protein ligase, is implicated in setting the threshold of T lymphocyte activation. The p85 regulatory subunit of phosphatidylinositol 3 kinase (PI3K) was identified as a substrate for Cbl-b. We have shown that Cbl-b negatively regulated p85 in a proteolysis-independent manner. Cbl-b is involved in the recruitment of p85 to CD28 and T cell antigen receptor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CBLB PIK3R1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 693134 | |
| CBLB PIK3R1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PIK3R1 CBLB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CBLB PIK3R1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID