BAIT
AQP1
AQP-CHIP, CHIP28, CO
aquaporin 1 (Colton blood group)
GO Process (46)
GO Function (12)
GO Component (15)
Gene Ontology Biological Process
- ammonium transmembrane transport [IDA]
- ammonium transport [IDA]
- bicarbonate transport [TAS]
- cGMP biosynthetic process [IDA]
- carbon dioxide transmembrane transport [IDA]
- carbon dioxide transport [IDA]
- cation transmembrane transport [IDA]
- cell volume homeostasis [IMP]
- cellular homeostasis [IDA]
- cellular hyperosmotic response [IMP]
- cellular response to UV [IDA]
- cellular response to cAMP [IDA, IEP]
- cellular response to copper ion [IDA]
- cellular response to dexamethasone stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to hypoxia [IDA]
- cellular response to inorganic substance [IDA]
- cellular response to mechanical stimulus [IDA]
- cellular response to mercury ion [IDA]
- cellular response to nitric oxide [IDA]
- cellular response to retinoic acid [IDA]
- cellular response to salt stress [IDA]
- cellular response to stress [IDA]
- cellular water homeostasis [IBA]
- cerebrospinal fluid secretion [IEP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- glycerol transport [IDA]
- lateral ventricle development [IEP]
- maintenance of symbiont-containing vacuole by host [IMP]
- multicellular organismal water homeostasis [IEP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- nitric oxide transport [IDA]
- odontogenesis [IEP]
- pancreatic juice secretion [IEP]
- positive regulation of angiogenesis [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of saliva secretion [IMP]
- potassium ion transmembrane transport [IMP, ISS]
- potassium ion transport [ISS]
- renal water transport [IDA]
- response to drug [IDA]
- small molecule metabolic process [TAS]
- transepithelial water transport [IDA]
- transmembrane transport [TAS]
- water transport [IDA, IMP, TAS]
Gene Ontology Molecular Function- ammonium transmembrane transporter activity [IDA]
- carbon dioxide transmembrane transporter activity [IDA, TAS]
- glycerol channel activity [IBA]
- glycerol transmembrane transporter activity [IDA]
- intracellular cGMP activated cation channel activity [IDA]
- nitric oxide transmembrane transporter activity [IDA]
- potassium channel activity [IMP]
- potassium ion transmembrane transporter activity [ISS]
- protein binding [IPI]
- transmembrane transporter activity [IDA]
- water channel activity [EXP, IDA, IMP]
- water transmembrane transporter activity [IDA]
- ammonium transmembrane transporter activity [IDA]
- carbon dioxide transmembrane transporter activity [IDA, TAS]
- glycerol channel activity [IBA]
- glycerol transmembrane transporter activity [IDA]
- intracellular cGMP activated cation channel activity [IDA]
- nitric oxide transmembrane transporter activity [IDA]
- potassium channel activity [IMP]
- potassium ion transmembrane transporter activity [ISS]
- protein binding [IPI]
- transmembrane transporter activity [IDA]
- water channel activity [EXP, IDA, IMP]
- water transmembrane transporter activity [IDA]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border [IDA]
- brush border membrane [IDA]
- cytoplasm [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- nuclear membrane [IDA]
- nucleus [IDA]
- plasma membrane [IDA, TAS]
- sarcolemma [IDA]
- symbiont-containing vacuole [ISS]
- symbiont-containing vacuole membrane [IDA]
Homo sapiens
PREY
CREB3
LUMAN, LZIP, sLZIP
cAMP responsive element binding protein 3
GO Process (20)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- cytoplasmic sequestering of transcription factor [IDA]
- establishment of viral latency [IDA]
- induction of positive chemotaxis [IDA, IMP]
- negative regulation of cell cycle [NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of deacetylase activity [IDA]
- positive regulation of defense response to virus by host [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell growth [IDA]
- regulation of cell proliferation [IMP]
- release from viral latency [IDA, TAS]
- response to endoplasmic reticulum stress [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [IMP]
- Golgi membrane [IDA]
- cytoplasm [IDA, IMP]
- cytosol [IMP]
- endoplasmic reticulum [IDA, IMP]
- endoplasmic reticulum membrane [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- integral component of membrane [IDA]
- membrane [IDA]
- neuronal cell body [IDA]
- nuclear body [IDA]
- nucleus [IC, IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread macromolecular interaction perturbations in human genetic disorders.
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays. The majority of disease-associated alleles exhibit wild-type chaperone binding profiles, ... [more]
Cell Apr. 23, 2015; 161(3);647-60 [Pubmed: 25910212]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CREB3 AQP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID