BAIT
CYP4F2
CPF2
cytochrome P450, family 4, subfamily F, polypeptide 2
GO Process (25)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- arachidonic acid metabolic process [IDA, TAS]
- blood coagulation [TAS]
- drug metabolic process [IMP]
- epoxygenase P450 pathway [IDA]
- icosanoid metabolic process [TAS]
- leukotriene B4 catabolic process [IDA]
- leukotriene metabolic process [TAS]
- long-chain fatty acid metabolic process [IDA]
- menaquinone catabolic process [IDA]
- negative regulation of blood coagulation [IMP]
- negative regulation of icosanoid secretion [IMP]
- omega-hydroxylase P450 pathway [TAS]
- oxidation-reduction process [IDA]
- phylloquinone catabolic process [IDA]
- positive regulation of icosanoid secretion [IMP]
- pressure natriuresis [IEP]
- regulation of blood pressure [IMP]
- renal water homeostasis [IEP]
- small molecule metabolic process [TAS]
- sodium ion homeostasis [IEP]
- very long-chain fatty acid metabolic process [IDA]
- vitamin E metabolic process [IDA]
- vitamin K biosynthetic process [IMP]
- vitamin K catabolic process [IDA]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- alkane 1-monooxygenase activity [IDA]
- alpha-tocopherol omega-hydroxylase activity [IDA]
- arachidonic acid epoxygenase activity [IDA]
- arachidonic acid omega-hydroxylase activity [IDA]
- leukotriene-B4 20-monooxygenase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IDA]
- protein binding [IPI]
- tocotrienol omega-hydroxylase activity [IDA]
- vitamin-K-epoxide reductase (warfarin-sensitive) activity [IMP]
- alkane 1-monooxygenase activity [IDA]
- alpha-tocopherol omega-hydroxylase activity [IDA]
- arachidonic acid epoxygenase activity [IDA]
- arachidonic acid omega-hydroxylase activity [IDA]
- leukotriene-B4 20-monooxygenase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IDA]
- protein binding [IPI]
- tocotrienol omega-hydroxylase activity [IDA]
- vitamin-K-epoxide reductase (warfarin-sensitive) activity [IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
CREB3
LUMAN, LZIP, sLZIP
cAMP responsive element binding protein 3
GO Process (20)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- cytoplasmic sequestering of transcription factor [IDA]
- establishment of viral latency [IDA]
- induction of positive chemotaxis [IDA, IMP]
- negative regulation of cell cycle [NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of deacetylase activity [IDA]
- positive regulation of defense response to virus by host [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell growth [IDA]
- regulation of cell proliferation [IMP]
- release from viral latency [IDA, TAS]
- response to endoplasmic reticulum stress [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [IMP]
- Golgi membrane [IDA]
- cytoplasm [IDA, IMP]
- cytosol [IMP]
- endoplasmic reticulum [IDA, IMP]
- endoplasmic reticulum membrane [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- integral component of membrane [IDA]
- membrane [IDA]
- neuronal cell body [IDA]
- nuclear body [IDA]
- nucleus [IC, IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread macromolecular interaction perturbations in human genetic disorders.
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays. The majority of disease-associated alleles exhibit wild-type chaperone binding profiles, ... [more]
Cell Apr. 23, 2015; 161(3);647-60 [Pubmed: 25910212]
Throughput
- High Throughput
Curated By
- BioGRID