AIFM1
Gene Ontology Biological Process
- DNA catabolic process [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [IMP]
- chromosome condensation [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- mitochondrial respiratory chain complex I assembly [IMP]
- neuron differentiation [IDA]
- positive regulation of apoptotic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC25A5
Gene Ontology Biological Process
- adenine transport [TAS]
- energy reserve metabolic process [TAS]
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IMP]
- positive regulation of cell proliferation [IMP]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Apoptosis Inducing Factor Binding Protein PGAM5 Triggers Mitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activity of X-Linked Inhibitor of Apoptosis.
Apoptosis inducing factor (AIF) plays a well-defined role in controlling cell death but is also a critical factor for maintaining mitochondrial energy homeostasis; how these dueling activities are balanced has remained largely elusive. To identify new AIF binding partners that may define the continuum of AIF cellular regulation, a biochemical screen was performed that identified the mitochondrial phosphoglycerate mutase 5 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AIFM1 SLC25A5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID