BAIT
CDH1
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
cadherin 1, type 1, E-cadherin (epithelial)
GO Process (17)
GO Function (7)
GO Component (16)
Gene Ontology Biological Process
- adherens junction organization [IMP, TAS]
- apoptotic process [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to lithium ion [IDA]
- establishment of protein localization to plasma membrane [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- homophilic cell adhesion via plasma membrane adhesion molecules [NAS]
- negative regulation of cell-cell adhesion [IMP]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to plasma membrane [IDA]
- regulation of immune response [TAS]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- aggresome [IDA]
- apical junction complex [IDA]
- catenin complex [IDA]
- cell junction [IDA, TAS]
- cell-cell adherens junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [IDA]
- lateral plasma membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- trans-Golgi network [IMP]
Homo sapiens
PREY
MYH9
BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA, RP1-68O2.1
myosin, heavy chain 9, non-muscle
GO Process (16)
GO Function (12)
GO Component (20)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- actin cytoskeleton reorganization [IMP]
- actin filament-based movement [IDA]
- actomyosin structure organization [IDA]
- angiogenesis [IDA]
- axon guidance [TAS]
- blood vessel endothelial cell migration [IMP]
- cytokinesis [IMP]
- integrin-mediated signaling pathway [NAS]
- leukocyte migration [NAS]
- membrane protein ectodomain proteolysis [IDA]
- monocyte differentiation [IEP]
- platelet aggregation [IMP]
- platelet formation [IMP]
- protein transport [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- actin cytoskeleton [IDA]
- actomyosin [IDA]
- actomyosin contractile ring [IDA]
- cell leading edge [IDA]
- cleavage furrow [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [IDA]
- integrin complex [IDA]
- membrane [IDA]
- myosin II complex [IDA]
- myosin II filament [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [IDA]
- ruffle [IDA]
- stress fiber [IDA]
- uropod [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extracellular cadherin domains and is regulated by an assembly of intracellular adaptors and enzymes associated with its cytoplasmic tail. We used proximity biotinylation and quantitative proteomics to identify 561 proteins in the vicinity of the ... [more]
Sci Signal Dec. 02, 2014; 7(354);rs7 [Pubmed: 25468996]
Throughput
- High Throughput
Curated By
- BioGRID