Co-crystal Structure

Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione.

Liang Q, Liu R, Du S, Ding Y

The NADPH-dependent human carbonyl reductase 1 (hCBR1), a member of the short-chain dehydrogenase/reductase protein family, plays an important role in the ubiquitous metabolism of endogenous and xenobiotic carbonyl containing compounds. Glutathione (GSH) is also a cofactor of hCBR1, however, its role in the carbonyl reductase function of the enzyme is still unclear. In this study, we presented the crystal structure ... [more]

J. Struct. Biol. Oct. 01, 2015; 192(1);138-44 [Pubmed: 26381805]

Throughput

  • Low Throughput

Curated By

  • BioGRID