TGFA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ADAM17
Gene Ontology Biological Process
- B cell differentiation [ISS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- Notch receptor processing [IDA]
- PMA-inducible membrane protein ectodomain proteolysis [IDA, IMP]
- T cell differentiation in thymus [ISS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- cell adhesion [IDA]
- cell adhesion mediated by integrin [IDA]
- cell motility [ISS]
- collagen catabolic process [TAS]
- epidermal growth factor receptor signaling pathway [IDA, TAS]
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- germinal center formation [ISS]
- membrane protein ectodomain proteolysis [IDA, IMP]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of interleukin-8 production [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- neutrophil mediated immunity [IC]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [ISS]
- positive regulation of chemokine production [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of epidermal growth factor-activated receptor activity [IDA, IMP]
- positive regulation of leukocyte chemotaxis [IC]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- proteolysis [IDA]
- regulation of mast cell apoptotic process [ISS]
- response to drug [ISS]
- response to high density lipoprotein particle [IDA]
- response to hypoxia [IDA]
- response to lipopolysaccharide [IDA]
- spleen development [ISS]
- wound healing, spreading of epidermal cells [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
DLG1/SAP97 modulates transforming growth factor alpha bioavailability.
TGFalpha and its receptor EGFR participate in the development of a wide range of tumors including gliomas, the main adult primary brain tumors. TGFalpha soluble form results from the cleavage by the metalloprotease TACE/ADAM17 of the extracellular part of its transmembrane precursor, pro-TGFalpha. To gain insights into the mechanisms underlying TGFalpha bioavailability, a yeast two-hybrid screen was performed to identify ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TGFA ADAM17 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | High | - | BioGRID | 1505010 |
Curated By
- BioGRID