BAIT

ALPL

AP-TNAP, APTNAP, HOPS, TNAP, TNSALP
alkaline phosphatase, liver/bone/kidney
GO Process (3)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

ALOX5

5-LO, 5-LOX, 5LPG, LOG5, RP11-67C2.3
arachidonate 5-lipoxygenase
Alzheimer's Disease Project
Homo sapiens

Biochemical Activity (Dephosphorylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.

Mahshid Y, Markoutsa S, Dincbas-Renqvist V, Sueruen D, Christensson B, Sander B, Bjoerkholm M, Sorg BL, Radmark O, Claesson HE

The key enzyme in leukotriene (LT) biosynthesis is 5-lipoxygenase (5-LO), which is expressed in myeloid cells and in B lymphocytes. There are three phosphorylation sites on 5-LO (Ser271, Ser523 and Ser663). Protein kinase A (PKA) phosphorylates 5-LO on Ser523. In this report, we demonstrate by immunoblotting that native 5-LO in mantle B cell lymphoma (MCL) cells (Granta519, JEKO1, and Rec1) ... [more]

Prostaglandins Leukot. Essent. Fatty Acids Sep. 01, 2015; 100();33-40 [Pubmed: 26210919]

Throughput

  • Low Throughput

Curated By

  • BioGRID