PIP5K1A
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of Rac GTPase activity [IMP]
- cell chemotaxis [IMP]
- cell migration [NAS]
- focal adhesion assembly [IMP]
- glycerophospholipid metabolic process [TAS]
- keratinocyte differentiation [TAS]
- phagocytosis [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [IDA, TAS]
- phospholipid biosynthetic process [IDA]
- phospholipid metabolic process [TAS]
- protein targeting to plasma membrane [IMP]
- ruffle assembly [IMP]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIP5K1C
Gene Ontology Biological Process
- actin cytoskeleton organization [TAS]
- adherens junction assembly [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- neutrophil chemotaxis [TAS]
- phagocytosis [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- single organismal cell-cell adhesion [TAS]
- small molecule metabolic process [TAS]
- synaptic vesicle endocytosis [TAS]
- synaptic vesicle exocytosis [TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999999112 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999999112, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PIP5K1A PIP5K1C | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1196832 | |
PIP5K1A PIP5K1C | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.0315 | BioGRID | 3584475 |
Curated By
- BioGRID