BAIT
GRB2
ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
growth factor receptor-bound protein 2
GO Process (20)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Ras protein signal transduction [TAS]
- T cell costimulation [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- cellular response to ionizing radiation [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IPI, TAS]
- leukocyte migration [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- receptor internalization [IMP]
- signal transduction in response to DNA damage [IMP]
Gene Ontology Molecular Function- SH3 domain binding [IDA]
- SH3/SH2 adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [IPI]
- identical protein binding [IPI]
- insulin receptor substrate binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- SH3 domain binding [IDA]
- SH3/SH2 adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [IPI]
- identical protein binding [IPI]
- insulin receptor substrate binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
NKX2-5
CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3
NK2 homeobox 5
GO Process (37)
GO Function (11)
GO Component (3)
Gene Ontology Biological Process
- adult heart development [IMP]
- atrial cardiac muscle cell development [ISS]
- atrial septum morphogenesis [IMP]
- cardiac conduction system development [IMP]
- cardiac muscle cell differentiation [ISS]
- cardiac muscle tissue morphogenesis [IMP]
- cell differentiation [ISS]
- embryonic heart tube development [ISS]
- heart looping [ISS]
- heart morphogenesis [ISS]
- hemopoiesis [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- negative regulation of transcription, DNA-templated [ISS]
- outflow tract septum morphogenesis [IMP]
- pharyngeal system development [ISS]
- positive regulation of cardioblast differentiation [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of heart contraction [ISS]
- positive regulation of neuron differentiation [IMP]
- positive regulation of sodium ion transport [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISS]
- positive regulation of transcription initiation from RNA polymerase II promoter [ISS]
- positive regulation of transcription via serum response element binding [ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of voltage-gated calcium channel activity [ISS]
- regulation of cardiac muscle contraction [ISS]
- right ventricular cardiac muscle tissue morphogenesis [IMP]
- septum secundum development [IMP]
- spleen development [IMP, ISS]
- thyroid gland development [IMP]
- vasculogenesis [ISS]
- ventricular cardiac muscle cell development [ISS]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- serum response element binding [ISS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- serum response element binding [ISS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.999997239 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999997239, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRB2 NKX2-5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3098641 |
Curated By
- BioGRID