WNT7A
Gene Ontology Biological Process
- Wnt signaling pathway involved in wound healing, spreading of epidermal cells [IDA]
- canonical Wnt signaling pathway [IDA]
- cartilage condensation [IDA]
- cell fate commitment [IBA]
- cell proliferation in forebrain [IDA]
- cellular response to transforming growth factor beta stimulus [IEP]
- chondrocyte differentiation [IDA]
- embryonic axis specification [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic forelimb morphogenesis [IMP]
- embryonic hindlimb morphogenesis [IMP]
- lens fiber cell development [ISS]
- negative regulation of neurogenesis [IDA]
- neuron differentiation [IBA]
- palate development [IMP]
- positive regulation of JNK cascade [IBA]
- positive regulation of epithelial cell proliferation involved in wound healing [IDA]
- positive regulation of synapse assembly [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- sex differentiation [TAS]
- stem cell development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAPK9
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- JNK cascade [IDA, TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- positive regulation of gene expression [IMP]
- positive regulation of macrophage derived foam cell differentiation [IMP]
- regulation of sequence-specific DNA binding transcription factor activity [TAS]
- response to stress [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.99996341 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.99996341, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
WNT7A MAPK9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 3109071 |
Curated By
- BioGRID