AGTR1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- Rho protein signal transduction [IDA]
- angiotensin-activated signaling pathway [IDA]
- calcium-mediated signaling [IDA]
- cell chemotaxis [IDA]
- kidney development [IMP]
- low-density lipoprotein particle remodeling [NAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [NAS]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, IPI]
- positive regulation of NAD(P)H oxidase activity [TAS]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol esterification [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of inflammatory response [TAS]
- positive regulation of macrophage derived foam cell differentiation [IC]
- positive regulation of phospholipase A2 activity [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- regulation of blood vessel size by renin-angiotensin [IC]
- regulation of cell growth [NAS]
- regulation of cell proliferation [NAS]
- regulation of inflammatory response [IC]
- regulation of renal sodium excretion [NAS]
- regulation of systemic arterial blood pressure by renin-angiotensin [IC]
- regulation of vasoconstriction [IC, IDA, NAS]
- regulation of vasodilation [IC]
- renin-angiotensin regulation of aldosterone production [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC6A8
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.996384147 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.996384147, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
AGTR1 SLC6A8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9644 | BioGRID | 1186547 | |
AGTR1 SLC6A8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9705 | BioGRID | 3102911 |
Curated By
- BioGRID