FAM19A4
GPLD1
Gene Ontology Biological Process
- GPI anchor release [IDA, IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to calcium ion [IDA]
- cellular response to cholesterol [IMP]
- cellular response to drug [IDA]
- cellular response to insulin stimulus [IDA]
- cellular response to pH [IDA]
- cellular response to triglyceride [IMP]
- chondrocyte differentiation [ISS]
- complement receptor mediated signaling pathway [IDA]
- hematopoietic stem cell migration [TAS]
- hematopoietic stem cell migration to bone marrow [TAS]
- insulin receptor signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of triglyceride catabolic process [ISS]
- ossification [ISS]
- phosphatidylcholine metabolic process [ISS, TAS]
- positive regulation of alkaline phosphatase activity [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of cytolysis [IDA]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of glucose metabolic process [ISS]
- positive regulation of high-density lipoprotein particle clearance [ISS]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of secretion [ISS]
- positive regulation of triglyceride biosynthetic process [ISS]
- regulation of cellular response to insulin stimulus [IDA]
- response to glucose [IDA]
- transepithelial transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.995967385 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.995967385, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FAM19A4 GPLD1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9934 | BioGRID | 3112154 |
Curated By
- BioGRID