TH
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- catecholamine biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- dopamine biosynthetic process [IDA]
- dopamine biosynthetic process from tyrosine [NAS]
- embryonic camera-type eye morphogenesis [ISS]
- epinephrine biosynthetic process [IDA]
- eye photoreceptor cell development [ISS]
- heart development [ISS]
- heart morphogenesis [NAS]
- learning [ISS]
- locomotory behavior [ISS]
- memory [ISS]
- norepinephrine biosynthetic process [IDA]
- organ morphogenesis [ISS]
- pigmentation [TAS]
- regulation of heart contraction [ISS]
- response to ethanol [IDA]
- response to hypoxia [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission, dopaminergic [ISS]
- visual perception [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TAOK2
Gene Ontology Biological Process
- G2 DNA damage checkpoint [IMP]
- actin cytoskeleton organization [IDA]
- activation of MAPKK activity [IDA]
- apoptotic process [NAS]
- cell migration [NAS]
- cellular response to DNA damage stimulus [IDA]
- focal adhesion assembly [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein targeting to membrane [NAS]
- regulation of cell growth [NAS]
- regulation of cell shape [IDA]
- response to stress [IDA]
- stress-activated MAPK cascade [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.994501834 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.994501834, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TH TAOK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9834 | BioGRID | 3139747 | |
TH TAOK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3261150 |
Curated By
- BioGRID