RGCC
Gene Ontology Biological Process
- cellular response to hypoxia [IMP]
- complement activation [IMP]
- fibroblast activation [ISS]
- mitotic cell cycle arrest [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion mediated by cadherin [IDA]
- negative regulation of cytokine secretion [IMP]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of exit from mitosis [IDA]
- negative regulation of fibroblast growth factor production [IDA]
- negative regulation of mitotic cell cycle phase transition [IDA]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of cytokine secretion [IMP]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA, IMP]
- positive regulation of extracellular matrix constituent secretion [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of stress fiber assembly [IDA]
Gene Ontology Molecular Function
TLN1
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell-cell junction assembly [TAS]
- cellular component movement [NAS]
- cellular protein metabolic process [TAS]
- cytoskeletal anchoring at plasma membrane [NAS]
- endoplasmic reticulum unfolded protein response [TAS]
- muscle contraction [TAS]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.992598098 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.992598098, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9995 | BioGRID | 1197349 | |
RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.947 | BioGRID | 3253685 | |
RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9937 | BioGRID | 3115216 |
Curated By
- BioGRID