EREG
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of MAPK activity [IBA]
- anatomical structure morphogenesis [TAS]
- cell-cell signaling [IDA]
- cytokine-mediated signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [IBA, ISS, TAS]
- female meiotic division [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- keratinocyte differentiation [TAS]
- keratinocyte proliferation [IDA]
- luteinizing hormone signaling pathway [ISS]
- mRNA transcription [IDA]
- negative regulation of cell proliferation [ISS]
- negative regulation of epithelial cell proliferation [TAS]
- negative regulation of smooth muscle cell differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- oocyte maturation [ISS]
- organ morphogenesis [TAS]
- ovarian cumulus expansion [ISS]
- ovulation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of DNA replication [IDA, ISS]
- positive regulation of cell proliferation [IDA, ISS]
- positive regulation of cytokine biosynthetic process [IDA]
- positive regulation of cytokine production [ISS]
- positive regulation of epidermal growth factor-activated receptor activity [ISS]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of innate immune response [ISS]
- positive regulation of interleukin-6 biosynthetic process [ISS]
- positive regulation of mitosis [ISS]
- positive regulation of phosphorylation [IDA, ISS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of smooth muscle cell proliferation [ISS]
- primary follicle stage [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB4A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.986377374 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.986377374, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
EREG RAB4A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9868 | BioGRID | 1197103 | |
EREG RAB4A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8834 | BioGRID | 3048336 |
Curated By
- BioGRID