UXT
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RUVBL2
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA, TAS]
- cellular response to UV [IMP]
- cellular response to estradiol stimulus [IMP]
- chromatin organization [TAS]
- chromatin remodeling [IMP]
- establishment of protein localization to chromatin [IMP]
- histone H2A acetylation [IDA]
- histone H4 acetylation [IDA]
- negative regulation of estrogen receptor binding [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein folding [TAS]
- transcriptional activation by promoter-enhancer looping [IMP]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [TAS]
- ATPase activity [IDA]
- DNA helicase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- identical protein binding [IDA, IPI]
- protein binding [IPI]
- unfolded protein binding [TAS]
- ATP-dependent DNA helicase activity [TAS]
- ATPase activity [IDA]
- DNA helicase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- identical protein binding [IDA, IPI]
- protein binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.969402603 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.969402603, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RUVBL2 UXT | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3368781 | |
| UXT RUVBL2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| RUVBL2 UXT | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9998 | BioGRID | 3161017 | |
| RUVBL2 UXT | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 424699 | |
| UXT RUVBL2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | Low | - | BioGRID | 2624098 |
Curated By
- BioGRID