BAIT
SETMAR
HsMar1, METNASE, Mar1
SET domain and mariner transposase fusion gene
GO Process (15)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA, IMP]
- DNA double-strand break processing [IDA]
- DNA integration [IMP]
- cell proliferation [IMP]
- double-strand break repair via nonhomologous end joining [IDA, IMP]
- histone H3-K36 dimethylation [IMP]
- histone H3-K36 methylation [IDA, IMP]
- histone H3-K4 methylation [IDA]
- mitotic DNA integrity checkpoint [IMP]
- negative regulation of cell cycle arrest [IMP]
- negative regulation of chromosome organization [IDA]
- nucleic acid phosphodiester bond hydrolysis [IMP]
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [IDA, IMP]
- positive regulation of double-strand break repair via nonhomologous end joining [IDA]
- replication fork processing [IMP]
Gene Ontology Molecular Function- DNA topoisomerase binding [IPI]
- double-stranded DNA binding [IMP]
- endonuclease activity [IDA, IMP]
- histone methyltransferase activity (H3-K36 specific) [IDA]
- histone methyltransferase activity (H3-K4 specific) [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- single-stranded DNA binding [IMP]
- single-stranded DNA endodeoxyribonuclease activity [IMP]
- structure-specific DNA binding [IDA, TAS]
- DNA topoisomerase binding [IPI]
- double-stranded DNA binding [IMP]
- endonuclease activity [IDA, IMP]
- histone methyltransferase activity (H3-K36 specific) [IDA]
- histone methyltransferase activity (H3-K4 specific) [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- single-stranded DNA binding [IMP]
- single-stranded DNA endodeoxyribonuclease activity [IMP]
- structure-specific DNA binding [IDA, TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
DOC2A
Doc2
double C2-like domains, alpha
GO Process (3)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.934085799 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.934085799, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID