AGT
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [TAS]
- angiotensin maturation [TAS]
- blood vessel remodeling [TAS]
- cell-cell signaling [TAS]
- cellular lipid metabolic process [TAS]
- cellular protein metabolic process [TAS]
- kidney development [IMP]
- low-density lipoprotein particle remodeling [NAS]
- negative regulation of endopeptidase activity [IBA]
- negative regulation of neurotrophin TRK receptor signaling pathway [IDA]
- negative regulation of sodium ion transmembrane transporter activity [TAS]
- nitric oxide mediated signal transduction [TAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [NAS]
- positive regulation of NAD(P)H oxidase activity [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of activation of JAK2 kinase activity [IMP]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA]
- positive regulation of cardiac muscle hypertrophy [ISS]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of cytokine production [TAS]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of epidermal growth factor receptor signaling pathway [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IDA]
- positive regulation of fibroblast proliferation [ISS]
- positive regulation of inflammatory response [TAS]
- positive regulation of macrophage derived foam cell differentiation [IC]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein tyrosine kinase activity [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of blood vessel size by renin-angiotensin [TAS]
- regulation of blood volume by renin-angiotensin [NAS]
- regulation of cell growth [NAS]
- regulation of cell proliferation [NAS]
- regulation of proteolysis [IBA]
- regulation of renal output by angiotensin [NAS]
- regulation of renal sodium excretion [NAS]
- regulation of vasoconstriction [NAS]
- renal system process [IDA]
- renin-angiotensin regulation of aldosterone production [NAS]
- response to muscle activity involved in regulation of muscle adaptation [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA5
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- ER-associated ubiquitin-dependent protein catabolic process [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- blood coagulation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucose starvation [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- maintenance of protein localization in endoplasmic reticulum [IMP]
- negative regulation of apoptotic process [IMP, TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cell migration [IMP]
- regulation of protein folding in endoplasmic reticulum [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- endoplasmic reticulum [IDA, IMP, TAS]
- endoplasmic reticulum chaperone complex [IDA]
- endoplasmic reticulum lumen [TAS]
- endoplasmic reticulum membrane [TAS]
- endoplasmic reticulum-Golgi intermediate compartment [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- membrane [IDA]
- midbody [IDA]
- nucleus [IDA, IMP]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.845725347 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.845725347, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
AGT HSPA5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7853 | BioGRID | 3140674 |
Curated By
- BioGRID