BAIT
EDNRB
ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A, RP11-318G21.1
endothelin receptor type B
GO Process (12)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cell surface receptor signaling pathway [TAS]
- endothelin receptor signaling pathway [IDA, IMP]
- enteric nervous system development [ISS]
- enteric smooth muscle cell differentiation [ISS]
- macrophage chemotaxis [IMP]
- negative regulation of adenylate cyclase activity [TAS]
- negative regulation of cellular protein metabolic process [IMP]
- negative regulation of neuron maturation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- nervous system development [TAS]
- vasoconstriction [IMP]
- vein smooth muscle contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EXOC1
BM-102, SEC3, SEC3L1, SEC3P, BM-012
exocyst complex component 1
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.792530981 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.792530981, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID