An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.

Publication

mBET3 is required for the organization of the TRAPP complexes.

Menon S, Cai H, Lu H, Dong G, Cai Y, Reinisch K, Ferro-Novick S

Large tethering complexes mediate the initial interaction of a transport vesicle with its target membrane. There are two forms of the multi-subunit tethering complex called TRAPP (TRAPPI and TRAPPII) that tether transport vesicles in different trafficking steps. Understanding TRAPP complex assembly and the protein-protein interactions among the subunits is an important step in elucidating the function of this tether. Here ... [more]

Biochem. Biophys. Res. Commun. Nov. 24, 2006; 350(3);669-77 [Pubmed: 17027922]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
TRAPPC3 TRAPPC1	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Pourhaghighi R (2020)	High	0.988	BioGRID	2676257
TRAPPC3 TRAPPC1	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Menon S (2006)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

TRAPPC3

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

TRAPPC1