PINK1
Gene Ontology Biological Process
- compound eye development [IMP]
- ectopic germ cell programmed cell death [IMP]
- mitochondrial fission [IGI]
- mitochondrion degradation [IMP]
- mitochondrion organization [IDA, IGI, IMP]
- negative regulation of mitochondrial fusion [IMP]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of programmed cell death [IMP]
- neuromuscular synaptic transmission [IMP]
- positive regulation of mitochondrial fission [IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of mitochondrion organization [IMP]
- response to oxidative stress [IMP]
- sperm mitochondrion organization [IMP]
Gene Ontology Molecular Function
DRP1
Gene Ontology Biological Process
- intracellular distribution of mitochondria [IMP]
- mitochondrion localization [IMP]
- mitochondrion organization [IMP]
- mitotic cytokinesis [IMP]
- positive regulation of mitochondrial fission [IMP]
- regulation of mitochondrial fission [IMP]
- sperm mitochondrion organization [IMP]
- synaptic vesicle budding from presynaptic membrane [NAS]
- ventral furrow formation [IMP]
- vesicle organization [IMP]
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The PINK1/Parkin pathway regulates mitochondrial morphology.
Loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) or parkin genes, which encode a mitochondrially localized serine/threonine kinase and a ubiquitin-protein ligase, respectively, result in recessive familial forms of Parkinsonism. Genetic studies in Drosophila indicate that PINK1 acts upstream of Parkin in a common pathway that influences mitochondrial integrity in a subset of tissues, including flight muscle and dopaminergic neurons. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PINK1 DRP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| DRP1 PINK1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 727948 |