PINK1
Gene Ontology Biological Process
- compound eye development [IMP]
- ectopic germ cell programmed cell death [IMP]
- mitochondrial fission [IGI]
- mitochondrion degradation [IMP]
- mitochondrion organization [IDA, IGI, IMP]
- negative regulation of mitochondrial fusion [IMP]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of programmed cell death [IMP]
- neuromuscular synaptic transmission [IMP]
- positive regulation of mitochondrial fission [IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of mitochondrion organization [IMP]
- response to oxidative stress [IMP]
- sperm mitochondrion organization [IMP]
Gene Ontology Molecular Function
DRP1
Gene Ontology Biological Process
- intracellular distribution of mitochondria [IMP]
- mitochondrion localization [IMP]
- mitochondrion organization [IMP]
- mitotic cytokinesis [IMP]
- positive regulation of mitochondrial fission [IMP]
- regulation of mitochondrial fission [IMP]
- sperm mitochondrion organization [IMP]
- synaptic vesicle budding from presynaptic membrane [NAS]
- ventral furrow formation [IMP]
- vesicle organization [IMP]
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery.
Mitochondria form dynamic tubular networks that undergo frequent morphological changes through fission and fusion, the imbalance of which can affect cell survival in general and impact synaptic transmission and plasticity in neurons in particular. Some core components of the mitochondrial fission/fusion machinery, including the dynamin-like GTPases Drp1, Mitofusin, Opa1, and the Drp1-interacting protein Fis1, have been identified. How the fission ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PINK1 DRP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| PINK1 DRP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| DRP1 PINK1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 727948 |