TFAP-2
Gene Ontology Biological Process
- adult feeding behavior [IMP]
- adult locomotory behavior [IMP]
- imaginal disc-derived leg joint morphogenesis [IMP]
- imaginal disc-derived leg morphogenesis [IMP]
- imaginal disc-derived male genitalia development [IMP]
- inter-male aggressive behavior [IGI]
- male courtship behavior [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- proboscis development [IMP]
- regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function
CG10440
Gene Ontology Biological Process
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila.
In Drosophila, the monoamine octopamine, through mechanisms that are not completely understood, regulates both aggression and mating behavior. Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine β-hydroxylase and Vesicular monanime transporter, genes necessary for octopamine ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TFAP-2 CG10440 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| CG10440 TFAP-2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |