A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster.

Williams MJ, Goergen P, Rajendran J, Zheleznyakova G, Haegglund MG, Perland E, Bagchi S, Kalogeropoulou A, Khan Z, Fredriksson R, Schioeth HB

In all animals managing the size of individual meals and frequency of feeding is crucial for metabolic homeostasis. In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Loss of TfAP-2 or Twz in octopaminergic neurons ... [more]

PLoS Genet. Sep. 01, 2014; 10(9);e1004499 [Pubmed: 25187989]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
TFAP-2 CG10440	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Williams MJ (2014)	Low	-	FlyBase	-
CG10440 TFAP-2	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Giot L (2003)	High	-	BioGRID	-

Curated By

FlyBase

Interaction Summary

TFAP-2

Gene Ontology Biological Process

Gene Ontology Molecular Function

sequence-specific DNA binding [IDA]sequence-specific DNA binding transcription factor activity [IDA, ISS]

Gene Ontology Cellular Component

CG10440