BAIT

REC12

spo11, SPAC17A5.11
endonuclease Rec12
Schizosaccharomyces pombe (972h)
PREY

SGO1

SPBP35G2.03c
inner centromere protein, shugoshin, Sgo1
Schizosaccharomyces pombe (972h)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions.

Katsumata K, Hirayasu A, Miyoshi J, Nishi E, Ichikawa K, Tateho K, Wakuda A, Matsuhara H, Yamamoto A

During meiotic prophase, telomeres cluster, forming the bouquet chromosome arrangement, and facilitate homologous chromosome pairing. In fission yeast, bouquet formation requires switching of telomere and centromere positions. Centromeres are located at the spindle pole body (SPB) during mitotic interphase, and upon entering meiosis, telomeres cluster at the SPB, followed by centromere detachment from the SPB. Telomere clustering depends on the ... [more]

PLoS Genet. Sep. 01, 2016; 12(9);e1006304 [Pubmed: 27611693]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: chromosome segregation (APO:0000208)

Additional Notes

  • double mutants show increased equational chromatid segregation

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
REC12 SGO1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
519661
SGO1 REC12
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
561865

Curated By

  • BioGRID