BAIT

SGO1

SPBP35G2.03c
inner centromere protein, shugoshin, Sgo1
Schizosaccharomyces pombe (972h)
PREY

REC12

spo11, SPAC17A5.11
endonuclease Rec12
Schizosaccharomyces pombe (972h)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Repositioning of aurora B promoted by chiasmata ensures sister chromatid mono-orientation in meiosis I.

Sakuno T, Tanaka K, Hauf S, Watanabe Y

During meiosis I, kinetochores of sister chromatids are juxtaposed or fused and mono-orient, while homologous chromosomes that are paired by chiasmata (bivalents) have to biorient. In the absence of chiasmata, biorientation of sister chromatids (univalents), which carries a risk of aneuploidy, has been occasionally detected in several species, including humans. We show in fission yeast that biorientation of fused sister ... [more]

Dev. Cell Sep. 13, 2011; 21(3);534-45 [Pubmed: 21920317]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: chromosome segregation (APO:0000208)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
REC12 SGO1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
519661
REC12 SGO1
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2333043

Curated By

  • BioGRID