BAIT

STMN1

C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, RP1-125I3.5
stathmin 1
GO Process (5)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

FANCC

FA3, FAC, FACC, RP11-80I15.2
Fanconi anemia, complementation group C
Cell Cycle - Mitotic Spindle Assembly Project
Fanconi Anemia Project
GO Process (2)
GO Function (1)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

The Fanconi Anemia C Protein Binds to and Regulates Stathmin-1 Phosphorylation.

Magron A, Elowe S, Carreau M

The Fanconi anemia (FA) proteins are involved in a signaling network that assures the safeguard of chromosomes. To understand the function of FA proteins in cellular division events, we investigated the interaction between Stathmin-1 (STMN1) and the FA group C (FANCC) protein. STMN1 is a ubiquitous cytosolic protein that regulates microtubule dynamics. STMN1 activities are regulated through phosphorylation-dephosphorylation mechanisms that ... [more]

PLoS ONE Oct. 16, 2015; 10(10);e0140612 [Pubmed: 26466335]

Throughput

  • Low Throughput

Ontology Terms

  • hek-293 cell (BTO:0000007)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
STMN1 FANCC
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Low-BioGRID
-

Curated By

  • BioGRID