A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.

Suarez C, Carroll RT, Burke TA, Christensen JR, Bestul AJ, Sees JA, James ML, Sirotkin V, Kovar DR

Fission yeast cells use Arp2/3 complex and formin to assemble diverse filamentous actin (F-actin) networks within a common cytoplasm for endocytosis, division, and polarization. Although these homeostatic F-actin networks are usually investigated separately, competition for a limited pool of actin monomers (G-actin) helps to regulate their size and density. However, the mechanism by which G-actin is correctly distributed between rival ... [more]

Dev. Cell Jan. 12, 2015; 32(1);43-53 [Pubmed: 25543282]

Throughput

Low Throughput

Ontology Terms

phenotype: actin cytoskeleton morphology (APO:0000120)

Additional Notes

simultaneously O.E. actin and profilin together suppresses contractile ring and actin patch defects caused by O.E. either actin, or profilin alone

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC3 ACT1	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Balasubramanian MK (1994)	Low	-	BioGRID	246914
ACT1 CDC3	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Suarez C (2015)	Low	-	BioGRID	2334397
ACT1 CDC3	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	McCollum D (1999)	Low	-	BioGRID	737553
ACT1 CDC3	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Subramanian D (2013)	Low	-	BioGRID	863620
ACT1 CDC3	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Subramanian D (2013)	Low	-	BioGRID	863615

Curated By

BioGRID

Interaction Summary

CDC3

Gene Ontology Biological Process

Gene Ontology Molecular Function

actin monomer binding [IDA]guanyl-nucleotide exchange factor activity [IDA]

Gene Ontology Cellular Component

ACT1