HOMER1
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [ISO, TAS]
- behavioral response to cocaine [IMP]
- chemical homeostasis within a tissue [IMP]
- positive regulation of calcium ion transport [IMP]
- protein localization to synapse [ISO]
- regulation of calcium ion import [IMP]
- regulation of cation channel activity [IMP]
- regulation of store-operated calcium entry [IMP]
- response to calcium ion [ISO]
- skeletal muscle contraction [IMP]
- skeletal muscle fiber development [IMP]
Gene Ontology Molecular Function- G-protein coupled glutamate receptor binding [IBA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- type 5 metabotropic glutamate receptor binding [ISO]
- G-protein coupled glutamate receptor binding [IBA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- type 5 metabotropic glutamate receptor binding [ISO]
Gene Ontology Cellular Component
YWHAE
Gene Ontology Biological Process
- cerebral cortex development [IMP]
- hippocampus development [IMP]
- negative regulation of peptidyl-serine dephosphorylation [ISO]
- negative regulation of protein dephosphorylation [IDA]
- neuron migration [IGI, IMP]
- protein targeting [IDA]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
Gene Ontology Molecular Function- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
YWHAE HOMER1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID