SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLG3
Gene Ontology Biological Process
- embryo development [IBA]
- establishment of planar polarity [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- negative regulation of phosphatase activity [ISO]
- nervous system development [IBA]
- nucleotide phosphorylation [IBA]
- receptor clustering [IBA]
- receptor localization to synapse [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- phosphatase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- ubiquitin protein ligase binding [IPI]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- phosphatase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA]
- basolateral plasma membrane [IBA]
- cell-cell junction [IDA]
- cytoplasm [IDA]
- dendritic shaft [ISO]
- extracellular space [ISO]
- growth cone [ISO]
- neuronal cell body [ISO]
- plasma membrane [IDA]
- postsynaptic density [IBA, ISO]
- postsynaptic membrane [IBA]
- synapse [ISO]
- tight junction [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SYNGAP1 DLG3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
SYNGAP1 DLG3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2333262 | |
SYNGAP1 DLG3 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.5655 | BioGRID | 3500012 |
Curated By
- BioGRID