PSO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
MSH2
Gene Ontology Biological Process
- DNA recombination [IMP]
- chromatin silencing at silent mating-type cassette [IGI]
- interstrand cross-link repair [IGI]
- maintenance of DNA repeat elements [IBA]
- meiotic gene conversion [IMP]
- meiotic mismatch repair [IMP]
- mismatch repair [IMP]
- mitotic recombination [IMP]
- negative regulation of reciprocal meiotic recombination [IBA]
- postreplication repair [IBA]
- removal of nonhomologous ends [IGI, IMP]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- DNA insertion or deletion binding [IDA]
- DNA-dependent ATPase activity [IBA]
- Y-form DNA binding [IDA]
- damaged DNA binding [IBA]
- double-strand/single-strand DNA junction binding [IDA]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA]
- heteroduplex DNA loop binding [IDA]
- single base insertion or deletion binding [IDA, IMP]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA insertion or deletion binding [IDA]
- DNA-dependent ATPase activity [IBA]
- Y-form DNA binding [IDA]
- damaged DNA binding [IBA]
- double-strand/single-strand DNA junction binding [IDA]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA]
- heteroduplex DNA loop binding [IDA]
- single base insertion or deletion binding [IDA, IMP]
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimately, cell death. High-throughput screens of human cancer cell-lines identify colorectal and gastric cell-lines with microsatellite instability (MSI) as enriched for cellular sensitivity ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PSO2 MSH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 163849 | |
| PSO2 MSH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 264036 | |
| PSO2 MSH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 721342 |
Curated By
- BioGRID