BAIT
MYO2
CDC66, myosin 2, L000001223, YOR326W
Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication
GO Process (10)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- Golgi inheritance [IMP]
- budding cell apical bud growth [IMP]
- establishment of mitotic spindle orientation [IMP, IPI]
- membrane addition at site of cytokinesis [IEP, IGI, IMP]
- mitochondrion inheritance [IGI, IMP, IPI]
- peroxisome inheritance [IMP, IPI]
- unidimensional cell growth [IMP]
- vacuole inheritance [IGI, IMP, IPI]
- vesicle transport along actin filament [IEP, IMP]
- vesicle-mediated transport [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SNF1
CAT1, CCR1, GLC2, HAF3, PAS14, AMP-activated serine/threonine-protein kinase catalytic subunit SNF1, L000001944, YDR477W
AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ubiquitin ligase
GO Process (12)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- cell adhesion [IMP]
- cellular response to nitrogen starvation [IDA]
- fungal-type cell wall assembly [IMP]
- invasive growth in response to glucose limitation [IMP]
- negative regulation of translation [IGI, IMP]
- positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [IMP]
- positive regulation of gluconeogenesis [IMP]
- protein phosphorylation [IDA]
- pseudohyphal growth [IMP]
- regulation of carbohydrate metabolic process [IGI, IPI]
- replicative cell aging [IGI, IMP]
- single-species surface biofilm formation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Fusion, fission, and transport control asymmetric inheritance of mitochondria and protein aggregates.
Partitioning of cell organelles and cytoplasmic components determines the fate of daughter cells upon asymmetric division. We studied the role of mitochondria in this process using budding yeast as a model. Anterograde mitochondrial transport is mediated by the myosin motor, Myo2. A genetic screen revealed an unexpected interaction of MYO2 and genes required for mitochondrial fusion. Genetic analyses, live-cell microscopy, ... [more]
J. Cell Biol. Aug. 07, 2017; 216(8);2481-2498 [Pubmed: 28615194]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Curated By
- BioGRID